Mental health challenges affect millions, yet too often, treatment only manages symptoms without addressing root causes. In this episode of the Dr. Hyman Show, Dr. Mark Hyman speaks with Standford psychiatrist Dr. Shebani Sethi, whose groundbreaking work confirms what many of us in natural health and functional medicine circles have long believed: mental health begins in the body.
Dr. Sethi explains that, by addressing metabolism and other physical aspects, we can restore energy to the brain, reduce inflammation, and help people reclaim clarity, resilience, and joy!
This episode offers not just hope, but a practical roadmap for anyone struggling with mental health or supporting a loved one through this challenge. Check it out below!
In this fascinating episode of The Dr. Hyman Show, Dr. Mark Hyman speaks with Stanford psychiatrist Dr. Shebani Sethi, the Clinical Associate Professor who founded the Metabolic Psychiatry Program—the first clinic in the world to unite psychiatry, nutrition, and metabolism.
Dr. Sethi coined the term Metabolic Psychiatry to capture a revolutionary truth: problems with metabolism—how your body produces and uses energy—may be driving depression, anxiety, bipolar disorder, and more. By healing the body, we may finally unlock lasting solutions for the brain.
What You’ll Learn in This Episode
This conversation shines a light on why the future of mental health may depend on treating whole-body dysfunction, not just brain chemistry. Dr. Sethi and Dr. Hyman explore:
- What metabolic psychiatry is and how it connects physical imbalances to mental illness
- The shocking link between insulin resistance and your risk for depression and other psychiatric conditions
- How poor metabolism creates brain energy deficits (cerebral glucose hypometabolism) that drive mood, memory, and focus issues
- The four key mechanisms of metabolic disease—inflammation, mitochondrial dysfunction, oxidative stress, and impaired plasticity—that damage the brain
- Evidence-based tools like the ketogenic diet, shown to reverse severe mental illness in just months
- The most important biomarkers and lab tests you can request to uncover hidden metabolic drivers of mental health struggles
- The future of psychiatry, where personalized metabolic care could transform how we prevent and treat mental illness
Rose.

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